About our group
The primary objective of our work is to design and synthesize new molecules as potential therapeutics and as tools for chemical biology. The research in our lab focuses on development of novel means of deciphering biological processes connected with viral replication such as host-virus interaction or control of innate immunity related to viral infection. Our major target are RNA viruses from Flaviviridae, Picornaviridae and Togaviridae families. Recently, we have invented highly selective chemical probes based on inhibition of phosphatidylinositol 4-kinase IIIβ, which are able to arrest replication of various important human pathogens by blockage of membrane remodeling initiated by these viruses. Apart from viral diseases, our projects aim at discovery of novel inhibitors of enzymes involved in pathology of neurodegenerative diseases and liver diseases or injury. We use modern medicinal chemistry approaches including fragment-based drug design and extensive molecular modeling for identification and optimization of hit compounds.